Paloxi

PALOXI® guesswork DESCRIPTION ® Paloxi (palonosetron hydrochloride) is an antiemetic and anti maladynt agent. It is a serotonin subtype 3 (5-HT3) receptor antagonist with a significant stick to affinity for this receptor. Chemically, palonosetron hydrochloride is: (3aS)-2-[(S)-1-Azabicyclo [2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1oxo-1Hbenz[de]isoquinoline hydrochloride. The empirical face is C19H24N2O.HCl, with a molecular clog of 332.87. Palonosetron hydrochloride exists as a single isomer and has the following geomorphologic formula: Palonosetron hydrochloride is a white to off -white crystalline powder. It is freely water- dissolvable in water, soluble in propylene glycol, and meagerly soluble in ethanol and 2 -propanol. ® Paloxi injection is a sterile, clear, colorless, non-pyrogenic, isotonic, buffered radical for intravenous ® administration. Each 5-ml vial of Paloxi injection contains 0.25 mg palonosetron crouch as hydrochloride, 207.5 mg mannitol, edetate disodium dihydrate, trisodium citratedihydrate, citric aci d monohydrate, and water for injection for intravenous administration. The pH of the solution is 4.5 to 5.5.

CLINICAL PHARMACOLOGY tool of Action Palonosetron is a 5-HT3 receptor antagonist with a strong binding affinity for this receptor and litt le or no affinity for other receptors. Cancer chemotherapy may be associated with a high incidence of malady and vomiting, particularly when certain agents, such as cisplatin, are used. 5-HT3 receptors are located on the heart and soul terminals of the vagus in the periphery and centrally in the chemorecepto r prod zone of the area postrema. It is th! ought that chemotherapeutic agents produce nausea and vomiting by releasing serotonin from the enterochromaffin cells of the small bowel and that the released s erotonin then activates 5-HT3 receptors located on vagal afferents to design father the vomiting reflex. Pharmacodynamics The effect of palonosetron on blood pressure, heart rate, and electrocardiogram parameters including QTc...If you want to get a full essay, disposition it on our website: BestEssayCheap.com

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